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Lab Code KIT-DNAB_THY Test/Profile Description Discover how your genes control the production of thyroid hormones, and how variations in your DNA might impact on their effectiveness, and ultimately your health. Extra Information Fasting not required. Test Name DNA Blue Thyroid Genetics Profile or Test? Profile Test Inclusions
DIO1 - Thyroid Hormone Activation
“D1” is largely expressed in the liver and kidneys. It is responsible for the clearance of rT3 from circulation, and for facilitating the conversion of T4 to T3 in plasma and surrounding tissue. This process requires selenium and iodine for optimum function. Here we look at two variants linked to poor conversion of T4 to T3 and
reduced clearance of RT3.
DIO2 - Thyroid Hormone Activation
“D2” is importantly expressed in the central nervous system, pituitary, brown fat tissue and muscle, and responds to changes in thyroid levels. D2 is responsible for the ‘local’ conversion of T4 to T3 in the thyroid, placenta and brain. It requires selenium and iodine to function optimally. Here we look at two different variants linked to decreased T4 and low mood in certain individuals.
COMT - Inactivation of Stress Hormones and Oestrogen
COMT is one of the main inactivating enzymes of stress hormones and oestrogen in the body. COMT variants cause slow clearance of stress hormones and oestrogen leading to high oestrogen and stress hormone levels which may also be linked to thyroid hormone dysfunction.
FKBP5 - Cortisol Regulation
FKBP5 is an important stress-regulating gene responsible for lowering cortisol levels after a stress response. Variants are associated with prolonged and increased symptoms of stress, which may be due to delayed lowering of cortisol levels.
PDE8B - TSH Signalling
PDE8B is found in the thyroid but not the pituitary, and is involved in TSH signalling. It is thought that the variant decreases the response of the thyroid gland to TSH stimulation
TNF-a - Inflammation
TNF-a is an inflammatory cytokine that helps regulate the immune reaction involved in inflammation, giving rise to fever and inhibiting tumour growth. If poorly controlled, it may be implicated in a number of autoimmune disorders. Variants in TNFa are associated with overreactive immune responses and prolonged inflammation.
TSHR - Thyroid Stimulating Hormone (TSH) Receptor
The TSHR gene plays a central role in thyroid metabolism bycontrolling the thyroid gland’s receptivity to TSH. Variants in this gene have been linked to hyperthyroidism, particularly to Graves’ Disease (GD).
TRHR - Thyrotropin Releasing Hormone (TRH) Receptor
Responsible for the body’s receptivity to TRH which stimulates the secretion of TSH from the pituitary gland. In turn, TSH stimulates the production of thyroid hormones from the thyroid gland. TRH is an important part of the negative feedback loop that ultimately regulates thyroid hormone levels. Variants have been shown to affect TSH levels.
The information provided is strictly for educational purposes and is not intended for diagnostic or treatment purposes and should not
be used as a substitute for professional medical advice. Use the information provided solely at your own risk. If you have any concerns about your health, please consult a qualified health professional.
Pathology Sample Swab Target Turn Around Time in working days 4-6 weeks Laboratory Notes THIS TEST IS ONLY AVAILABLE FOR 18'S AND OVER. Full instructions included for swabbing your cheek Sample Containers No Special Notes N/A GP Referral Yes Included
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Company No. 06787096Tavyside Health Centre
Abbey Rise, Tavistock
Devon PL19 9FD
Phone: 0800 999 1110
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