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DNA Blue Thyroid Genetics

DNA Blue Thyroid Genetics


DNA Blue Thyroid Genetics

Quick Overview

Discover how your genes control the production of thyroid hormones, and how variations in your DNA might impact on their effectiveness, and ultimately your health. Your DNA is like an instruction manual responsible for controlling every single function that takes place in your body. Via a simple DIY cheek swab you will discover thyroid related markers in your unique DNA code that influence:

  • Your Pituitary Gland's receptivity to TRH which stimulates the secretion of TSH

  • Your Thyroid Gland's receptivity to TSH

  • Your Thyroid Gland's receptivity to TSH signalling

  • Conversion of T4 to T3

  • The clearing of RT3 from circulation

  • Your Body's response to stress

  • Detoxification of compounds that impact thyroid hormone levels

  • Your Body's response and susceptability to inflammation and infection, both of which affect thyroid function.

Along with the above information, we provide a Nutrition and Lifestyle Guide developed by specialists to help you to make the most out of the information and advice given.

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Test/Profile Description Discover how your genes control the production of thyroid hormones, and how variations in your DNA might impact on their effectiveness, and ultimately your health.
Extra Information Fasting not required.
Test Name DNA Blue Thyroid Genetics
Profile or Test? Profile
Test Inclusions

DIO1 - Thyroid Hormone Activation

“D1” is largely expressed in the liver and kidneys. It is responsible for the clearance of rT3 from circulation, and for facilitating the conversion of T4 to T3 in plasma and surrounding tissue. This process requires selenium and iodine for optimum function. Here we look at two variants linked to poor conversion of T4 to T3 and
reduced clearance of RT3.

DIO2 - Thyroid Hormone Activation

“D2” is importantly expressed in the central nervous system, pituitary, brown fat tissue and muscle, and responds to changes in thyroid levels. D2 is responsible for the ‘local’ conversion of T4 to T3 in the thyroid, placenta and brain. It requires selenium and iodine to function optimally. Here we look at two different variants linked to decreased T4 and low mood in certain individuals.

COMT - Inactivation of Stress Hormones and Oestrogen

COMT is one of the main inactivating enzymes of stress hormones and oestrogen in the body. COMT variants cause slow clearance of stress hormones and oestrogen leading to high oestrogen and stress hormone levels which may also be linked to thyroid hormone dysfunction.

FKBP5 - Cortisol Regulation

FKBP5 is an important stress-regulating gene responsible for lowering cortisol levels after a stress response. Variants are associated with prolonged and increased symptoms of stress, which may be due to delayed lowering of cortisol levels.

PDE8B - TSH Signalling

PDE8B is found in the thyroid but not the pituitary, and is involved in TSH signalling. It is thought that the variant decreases the response of the thyroid gland to TSH stimulation

TNF-a - Inflammation

TNF-a is an inflammatory cytokine that helps regulate the immune reaction involved in inflammation, giving rise to fever and inhibiting tumour growth. If poorly controlled, it may be implicated in a number of autoimmune disorders. Variants in TNFa are associated with overreactive immune responses and prolonged inflammation.

TSHR - Thyroid Stimulating Hormone (TSH) Receptor

The TSHR gene plays a central role in thyroid metabolism bycontrolling the thyroid gland’s receptivity to TSH. Variants in this gene have been linked to hyperthyroidism, particularly to Graves’ Disease (GD).

TRHR - Thyrotropin Releasing Hormone (TRH) Receptor

Responsible for the body’s receptivity to TRH which stimulates the secretion of TSH from the pituitary gland. In turn, TSH stimulates the production of thyroid hormones from the thyroid gland. TRH is an important part of the negative feedback loop that ultimately regulates thyroid hormone levels. Variants have been shown to affect TSH levels.

The information provided is strictly for educational purposes and is not intended for diagnostic or treatment purposes and should not
be used as a substitute for professional medical advice. Use the information provided solely at your own risk. If you have any concerns about your health, please consult a qualified health professional.

Pathology Sample Swab
Target Turn Around Time in working days 4-6 weeks
Laboratory Notes THIS TEST IS ONLY AVAILABLE FOR 18'S AND OVER. Full instructions included for swabbing your cheek
Sample Containers No
Special Notes N/A
GP Referral Yes Included
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